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How to administer AJOVY

The easy-to-use Autoinjector for AJOVY1

Features of the AJOVY Autoinjector

AJOVY Autoinjector
  • No visible needle

  • Window displays when dose has been delivered

  • Audible cues signal progress of injection

  • Button-free, push-down mechanism

97% of HCPs and patients found the AJOVY Autoinjector easy to use.

97% of HCP and patient evaluators found the AJOVY Autoinjector easy to use in two Human Factor studies (N=77)1*

*Two Human Factor studies assessed evaluators' ability to complete critical tasks in order to demonstrate use of the AJOVY Autoinjector in simulated-use sessions. When asked "Was the autoinjector easy to use?", 97% in study 1 (N=30) and 98% in study 2 (N=47) answered "Yes".1

Administration of AJOVY

AJOVY may be administered in office by a healthcare professional or at home by the patient
or caregiver.1 AJOVY is available in an autoinjector. Guidance on proper subcutaneous techniques should be provided.

AJOVY Autoinjector administration video

How to use the autoinjector for AJOVY® (fremanezumab-vfrm) injection.

Hi. I’m here to walk you through some instructions on how to use the autoinjector for AJOVY.

This video does not replace the complete Instructions For Use included with your autoinjector. Please read and follow the Instructions For Use before you start using your autoinjector for AJOVY and each time you get a refill.

If you still have questions after doing so, speak to your healthcare provider.

Preparing to use the autoinjector

Let’s get started. Whether you are injecting your AJOVY quarterly or once monthly, the process is very similar. First, remove your autoinjector from the refrigerator and wait for 30 minutes to allow the medicine to reach room temperature.

If your dose is 225 mg of AJOVY each month, remove one autoinjector.

If your dose is 675 mg of AJOVY every three months, take out three autoinjectors.

Do not shake the autoinjector.

Also, do not leave it in direct sunlight or try to warm it up using a heat source such as hot water or a microwave.

Now, wash your hands with soap and water and dry well with a clean towel.

Next, look closely at your autoinjector to make sure there is no visible damage such as cracks or leaks.

Ensure that the liquid inside is clear and colorless to slightly yellow.

If the liquid has any particles in it or is discolored, cloudy or frozen, do not use the autoinjector and call your healthcare provider or pharmacist.

If you see air bubbles in the autoinjector, don’t worry, as this is normal.

Be sure to check that “AJOVY” appears on the autoinjector and that the expiration date has not passed.

Choosing an injection area

You have a few options on where to inject your dose.

You can choose to inject your stomach area, but make sure to avoid about 2 inches around the belly button.

You can also inject in the front of either of your thighs at least 2 inches above the knee and at least 2 inches below the groin.

Or, you can inject on the fleshy areas at the back of either of your upper arms but you may need someone who has been instructed on how to give your injection to help you. If prescribed the 675 mg dose, avoid injecting in exactly the same place.

Using the autoinjector

To inject your dose of AJOVY, first clean the chosen injection area using a new alcohol swab and let your skin dry.

Now, pick up your autoinjector with one hand and pull the protective cap straight off with the other. Do not twist.

Throw the protective cap away immediately.

To give yourself the injection, place the blue end of the autoinjector at a 90-degree angle against your cleaned skin at the injection site.

Press down firmly on the autoinjector and you will hear a “CLICK” that means the injection has started.

Continue to hold down firmly for about 30 seconds.

As the medicine is being injected, the blue plunger will move to the bottom of the viewing window. After about 15 seconds, you will hear a second "CLICK."

Next, wait about 10 seconds to make sure all the medicine is injected.

Check that the blue plunger has filled the viewing window and remove the autoinjector from the skin by lifting straight up.

Now, use a clean, dry cotton ball or gauze pad to gently press on the injection site for a few seconds.

Put your used autoinjector in an FDA-approved sharps disposal or puncture-resistant container immediately after use.

Alright, there you have it. Please read the Instructions For Use. If you still have questions about these steps, I suggest speaking with your healthcare provider. You can also call the Shared Solutions® hotline at 1-800-887-8100 to be connected with a nurse who can answer your questions.


AJOVY is a prescription medicine used for the preventive treatment of migraine in adults.


Do not use AJOVY if you are allergic to AJOVY or any of the ingredients in AJOVY. AJOVY may cause allergic reactions, including itching, rash and hives that can happen within hours and up to 1 month after receiving AJOVY. Call your healthcare provider or get emergency medical help right away if you have any symptoms of an allergic reaction: swelling of your face, mouth, tongue, throat or if you have trouble breathing. Talk to your doctor about stopping AJOVY if you have an allergic reaction. Tell your healthcare provider about all the medicines you take and if you are pregnant, planning to become pregnant, or are breastfeeding. Common side effects of AJOVY include injection-site reactions. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of AJOVY. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report side effects to the FDA at 1-800-FDA-1088. Please see the Patient Information Leaflet within the full Prescribing Information at

How to use the AJOVY Autoinjector

Step 1

Autoinjector administration step 1

Uncap the autoinjector

With one hand, firmly pull the cap straight off the autoinjector (don’t twist) and throw the cap away immediately.

Step 2

Autoinjector administration step 2

Place at a 90° angle

Place the autoinjector at a 90° angle against your skin at your chosen injection site.

Step 3

Autoinjector administration step 3

Press down and hold autoinjector until 10 seconds after second click

Press down on the autoinjector. You will hear a click. This means the injection has started and you should see the blue plunger move down. You will hear a second click. Remove autoinjector 10 seconds after.

The above steps do not include the full administration instructions for the AJOVY Autoinjector.

Follow the links below to read the full Instructions for Use prior to administering AJOVY.

Storage and handling2

Store AJOVY in the refrigerator between 36°F to 46°F (2°C to 8°C).
Do not freeze.

Storage and handling PDF


  • AJOVY prefilled autoinjector is for single time (one-time) use only. Put AJOVY in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) your used sharps disposal container in your household trash
  • Before injecting, let AJOVY sit at room temperature for 30 minutes. Do not warm up the AJOVY prefilled autoinjector using a heat source such as hot water or a microwave
  • Keep AJOVY prefilled autoinjector out of the reach of small children
  • After you remove the protective cap from AJOVY, to prevent infection, do not touch the needle
  • Do not inject AJOVY in your veins (intravenously)
  • Do not re-use your AJOVY prefilled autoinjector, as this could cause injury or infection
  • Do not share your AJOVY prefilled autoinjector with another person. You may give another person an infection or get an infection from them

Sharps disposal PDF

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