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Autoinjector is available in a Triple Pack
Efficacy for AJOVY

More migraine-free days with as few as 4 injection days a year and results seen as early as one week1,2

Patients experienced significantly more migraine-free days with AJOVY vs placebo in the HALO + Long-Term Extension Studies1,2

See Study Design

Chronic migraine Episodic migraine
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Consider limitations of Long-Term Extension study design when interpreting efficacy results.

In episodic migraine, a reduction in monthly migraine days was demonstrated during the 12-week period (primary endpoint), with results seen as early as week 11,2

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Consider limitations of Long-Term Extension study design when interpreting efficacy results.

Patients randomized to quarterly dosing had a mean baseline of 13.2 headache days of at least moderate severity per month and experienced, on average1:
4.7 fewer headache days at month 3 vs 3.3 with placebo (P<0.001).1,2

Patients randomized to monthly dosing had a mean baseline of 12.8 headache days of at least moderate severity per month and experienced, on average1:
5.1 fewer headache days at month 3 vs 3.3 with placebo (P<0.001).1,2

*Reduction in monthly average number of headache days from the Long-Term Extension study was 6.8 with monthly dosing.2

Patients randomized to quarterly dosing had a mean baseline of 9.2 migraine days per month and experienced, on average1:
4.2 fewer migraine days at month 3 vs 3.1 with placebo (P<0.001).1,2

Patients randomized to monthly dosing had a mean baseline of 8.9 migraine days per month and experienced, on average1:
4.3 fewer migraine days at month 3 vs 3.1 with placebo (P<0.001).1,2

*Reduction in monthly average number of migraine days from the Long-Term Extension study was 5.1 with monthly dosing.2

In clinical trials, AJOVY reduced migraine days by 50% or more for some patients1

Chronic migraine Episodic migraine

Secondary endpoint1

Reduction

in monthly number of migrane days with quarterly dosing

37.6% vs 18.1%

with placebo
(P<0.001)

Exploratory analysis2

Reduction

in monthly number of migrane days with quarterly dosing

20% vs 10.4%

with placebo
(Exploratory analysis)

Exploratory analysis2

Reduction

in monthly number of migrane days with quarterly dosing

7.7% vs 4.2%

with placebo
(Exploratory analysis)

Secondary endpoint1

Reduction

in monthly number of migrane days with quarterly dosing

44.4% vs 27.9%

with placebo
(P<0.001)

Exploratory analysis2

Reduction

in monthly number of migrane days with quarterly dosing

25.8% vs 15.4%

with placebo
(Exploratory analysis)

Exploratory analysis2

Reduction

in monthly number of migrane days with quarterly dosing

8.5% vs 4.5%

with placebo
(Exploratory analysis)

Similar reductions seen with monthly dosing in chronic migraine patients†

†With monthly dosing, reduction in monthly average headache days of at least moderate severity: 40.8% of patients achieved a ≥50% reduction vs 18.1% with placebo (P<0.001), 20.6% achieved a ≥75% reduction vs 10.4% with placebo (exploratory analysis), and 7.5% achieved 100% reduction vs 4.2% for placebo (exploratory analysis).1,2

Similar reductions seen with monthly dosing in episodic migraine patients†

†With monthly dosing, reduction in monthly average migraine days: 47.7% of patients achieved a ≥50% reduction vs 27.9% with placebo (P<0.001), 27.2% achieved a ≥75% reduction vs 15.4% with placebo (exploratory analysis), and 10.1% achieved 100% reduction vs 4.5% for placebo (exploratory analysis).1,2

What to explore next

Clinical trial results for AJOVY Review Dosing Analyses
Quarterly dosing with AJOVY Learn about quarterly dosing
Most common AJOVY side effects Review side effects of AJOVY
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