You had searched for:

There were no results matching the query.

You can also browse the topics below to find what you are looking for.

Support Services

  1. Download the Prescription and Service Request Form (PSRF)
  2. Fax the completed form to Shared Solutions® at 1-844-257-6127

Patients can call 1-800-887-8100, Monday–Friday, 8 am–6 pm CT.

The mechanism of action of an anti-CGRP in the preventive treatment of migraine

AJOVY is a monoclonal antibody that selectively targets the CGRP ligand.1

CGRP migraine - AJOVY anti-CGRP moa

Patients experiencing migraine have increased levels of CGRP, a neuropeptide present in both the central and peripheral nervous system.2,3

CGRP binding to receptor - AJOVY anti-CGRP moa

When CGRP binds to its receptor, a cascade of events results, which contribute to neurogenic inflammation associated with migraine pain.2

AJOVY targeting the CGRP ligand - anti-cgrp moa

AJOVY selectively targets the CGRP ligand, which is believed to block this cascade of events, thereby preventing the activation of the trigeminal system.1,4

Watch MOA Video of AJOVY

Watch MOA Video of AJOVY

Suggestions to explore next

Continue to AJOVY Efficacy page

AJOVY helped significantly reduce monthly migraine days vs placebo1

Continue to AJOVY Dosing flexibility page

Flexibility to help you meet your patients' needs1

dosing options for ajovy
Continue to AJOVY Safety page

Safety profile in clinical trials for AJOVY1

safety profile for ajovy