AJOVY is available in an autoinjector. Learn more

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Patient Profiles


Maura

Anna

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Support Services

  1. Download the Prescription and Service Request Form (PSRF)
  2. Fax the completed form to Shared Solutions® at 1-844-257-6127

Patients can call 1-800-887-8100, Monday–Friday, 8 am–6 pm CT.

What makes
AJOVY different?

Pharmacokinetic profile that supports dosing only 4 times a year

Phase 1 study assessing Pharmacokinetic parameters1,2*

AJOVY was evaluated in a phase 1 study to assess pharmacokinetic parameters for both quarterly and monthly dosing in healthy volunteers1

Plasma concentrations of AJOVY were slightly higher at month 3 for quarterly dosing than at month 1 for monthly2

The relationship between pharmacokinetics and efficacy has not been established.

AJOVY has a
long half-life3
31 DAYS

This should be taken into consideration for women who are pregnant or plan to become pregnant while using AJOVY.

There are no adequate data on the developmental risk associated with the use of AJOVY in pregnant women.

AJOVY is a fully humanized monoclonal antibody

Target ligand
IgG
isotype
IgG2∆a3

This information should not be construed to imply any difference in safety, efficacy, or other clinical outcomes.

Mechanism of Action

CGRP migraine - AJOVY anti-CGRP MOA

Patients experiencing migraine have increased levels of CGRP, a neuropeptide present in both the central and peripheral nervous system.2,3

CGRP binding to receptor - AJOVY anti-CGRP MOA

When CGRP binds to its receptor, a cascade of events results, which contribute to neurogenic inflammation associated with migraine pain.2

AJOVY targeting the CGRP ligand - MOA

AJOVY selectively targets the CGRP ligand, which is believed to block this cascade of events, thereby preventing the activation of the trigeminal system.1,4

Watch MOA Video of AJOVY

Watch MOA Video of AJOVY

Suggestions to explore next

Continue to AJOVY clinical trial results page

AJOVY helped significantly reduce monthly migraine days vs placebo1

SEE THE CLINICAL TRIAL RESULTS FOR AJOVY
Continue to AJOVY Dosing page

Only 4 injection days per year with quarterly dosing

dosing for AJOVY
Continue to AJOVY side effects page

Safety profile in clinical trials for AJOVY2

side effects for ajovy