Administering AJOVY

Quarterly

675 mg (225 mg x 3) SQ

Only 4 injection days per year

or

Monthly

225 mg SQ

Only 1 injection per month

The only anti-CGRP treatment for the prevention of migraine with quarterly and monthly dosing options to help you meet your patients’ needs.1

If your patient is self-injecting, it is important to review all of the steps they should take before injection.

 

CGRP: calcitonin gene-related peptide; SQ: subcutaneous.

  1. Read this before you inject.
  2. Step 1. Check your prescription.

    AJOVY comes as a single-dose (1 time) prefilled syringe. Your healthcare provider will prescribe the dose that is best for you.

    • If your healthcare provider prescribes the 225 mg monthly dose for you, take 1 injection monthly, using a prefilled syringe.
    • If your healthcare provider prescribes the 675 mg every 3 months dose for you, take 3 separate injections one after another, using a different prefilled syringe for each injection. You will take these injections once every 3 months.

    Before you inject, always check the label of your single-dose prefilled syringe to make sure you have the correct medicine and the correct dose of AJOVY. If you are not sure of your dose, ask your healthcare provider.

  3. Step 2. Remove the prefilled syringe from the carton.

    • You may need to use more than 1 prefilled syringe based on your prescribed dose.
    • Hold the prefilled syringe (as shown in Figure C).
    • Remove the syringe from the carton.
    • Do not shake the prefilled syringe at any time, as this could affect the way the medicine works.

    Holding the prefilled syringe of AJOVY

    Figure C

  4. Step 3. Gather the supplies you will need to inject AJOVY.

      • Gather the following supplies (see Figure D) and the number of AJOVY 225 mg prefilled syringes you will need to give your prescribed dose:
        • If your dose is 225 mg, you will need 1 AJOVY 225 mg prefilled syringe.
        • If your dose is 675 mg, you will need 3 AJOVY 225 mg prefilled syringes.
        • alcohol swabs (not supplied).
        • gauze pads or cotton balls (not supplied).
        • sharps disposal or puncture-resistant container (not supplied).
    Supplies needed to inject AJOVY

    Figure D

  5. Step 4. Let AJOVY reach room temperature.

    • Place the supplies you have gathered on a clean, flat surface.
    • Wait for 30 minutes to allow the medicine to reach room temperature.
    • Do not leave the prefilled syringe in direct sunlight as this could damage the liquid medicine.
    • Do not warm up the AJOVY prefilled syringe using hot water, a microwave, or any other way than instructed as this could damage the liquid medicine.
    AJOVY needs to wait 30 minutes to reach room temperature
  6. Step 5. Wash your hands.

    • Wash your hands with soap and water and dry well with a clean towel. Be careful not to touch your face or hair after washing your hands.
  7. Step 6. Look closely at your AJOVY prefilled syringe.

    Note: You may see air bubbles in the prefilled syringe. This is normal. Do not remove the air bubbles from the prefilled syringe before giving your injection. Injecting AJOVY with these air bubbles will not harm you.

    • Check that the liquid medicine in the prefilled syringe is clear and colorless to slightly yellow before you give your injection. (See Figure E). If the liquid has any particles in it, or is discolored, cloudy, or frozen, do not use the prefilled syringe. Call your healthcare provider or pharmacist.
    • Do not use the prefilled syringe if it has any visible damage, such as cracks or leaks. See disposal instructions in Step 12.
    • Check that AJOVY appears on the prefilled syringe.
    • Do not use if you have been given the wrong medicine.
    • Check the expiration date printed on the prefilled syringe label.
    • Do not use the prefilled syringe if the expiration date has passed.

    The above checks are all important to make sure the medicine is safe to use.

    Closely inspect the pre-filled syringe to ensure it is AJOVY not expired or damaged

    Figure E

  8. Step 7. Choose your injection area.

      • Choose an injection area from the following areas (see Figure F):
        • your stomach area (abdomen), avoid about 2 inches around the belly button.
        • the front of your thighs, an area that is at least 2 inches above the knee and 2 inches below the groin.
        • the back of your upper arms, in the fleshy areas of the upper back portion.
    Stomach, thighs, or back of upper arm are areas that AJOVY can be injected to

    Figure F

    Note: There are some injection areas on your body that are hard to reach (like the back of your arm). You may need help from someone who has been instructed on how to give your injection if you cannot reach certain injection areas.

  9. Step 8. Clean your injection area.

    • Clean the chosen injection area using a new alcohol swab.
    • Wait 10 seconds to allow the skin to dry before injecting.
    • Do not inject AJOVY into an area that is tender, red, bruised, calloused, tattooed, hard, or that has scars or stretch marks.
    • Do not inject AJOVY in the same injection site that you inject other medicine.
    • If you want to use the same body site for the three separate injections needed for the 675 mg dose, make sure the second and third injections are not at the same spot you used for the other injections.
  10. Step 9. Remove needle cap and do not replace.

    • Pick up the body of the prefilled syringe with 1 hand.
    • Pull the needle cap straight off with your other hand (see Figure G). Do not twist.
    • Throw away the needle cap right away.
    • Do not put the needle cap back on the prefilled syringe, to avoid injury and infection.
     Remove cap of AJOVY prefilled syringe before use

    Figure G

  11. Step 10. Give your injection following the 4 steps below.

    1.  Use your free hand to gently pinch up at least 1 inch of the skin that you have cleaned. Gently pinch skin at least one inch
    2.  Insert the needle into the pinched skin at a 45 to 90 degree angle. Insert prefilled syringe of AJOVY into pinched skin
    3.  When the needle is all the way into your skin, use your thumb to push the plunger. Use thumb to push plunger of prefilled syringe of AJOVY
    4.  Push the plunger slowly all the way down as far as it will go to inject all of the medicine. Slowly push plunger of prefilled syringe of AJOVY all the way down
  12. Step 11. Remove the needle from your skin.

    • After you have injected all of the medicine, pull the needle straight out (see Figure H).
    • Do not recap the needle at any time, to avoid injury and infection.
     Remove prefilled syringe of AJOVY in an upward motion

    Figure H

  13. Step 12. Apply pressure at the injection site.

    • Use a clean, dry cotton ball or gauze to gently press on the injection site for a few seconds.
    • Do not rub the injection site
    • Do not re-use the prefilled syringe.
  14. Step 13. Dispose of your prefilled syringe right away.

    Dispose of prefilled syringe of AJOVY immediately after use
    • Put your used prefilled syringes, needles, and sharps in a FDA-cleared sharps disposal container right away after use.
    • Do not throw away (dispose of) loose needles, syringes, or prefilled syringes in your household trash. Do not recycle your used sharps disposal container.
    • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
      • made of a heavy-duty plastic,
      • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
      • upright and stable during use,
      • leak-resistant, and
      • properly labeled to warn of hazardous waste inside the container.
    • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
    • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.

    Injection Complete

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